Dim sTxt As String = "ABCD123E"
  Dim aChars() As Char = {"B"c, "2"c}
  Dim sRes As String = sTxt.Trim(aChars)
  Debug.WriteLine(sRes)

TIA
Corrado

The Trim method only works on the outermost characters of a string. Once it
gets to a character that isn't supposed to be trimmed then it stops
searching. Change your string to "BBB2BBBABCD123E222B222" and you'll see
what I mean.

If you want to remove a character then use the Replace() method.
Dim sRes As String = sTxt.Replace("B","")

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Corrado